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These reactions are typically mild, self-limiting, and resolve within a few days
Gclc fl/fl mice were described previously 127 and were crossed to Mb1-Cre + expressing mice 46 to obtain the Gclc fl/fl Mb1-cre strain
Weight changes (if they happen) typically track with the overall program and consistency rather than the injection alone
Structures of the glucagon receptor (GCGR), the closest homolog of GLP-1R, have revealed key differences between the peptide-free and peptide-bound states, including an interesting -sheet motif in the peptide-free structure comprised of the stalk region and extracellular loop 1 ( ECL1) 9,14
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