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Continued advancements in nanoparticle design and administration routes, such as receptor-mediated transcytosis and intranasal delivery, hold significant promise for translating GLP-1RAs therapies into effective, disease-modifying treatments for AD

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Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014