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216,217 Alcohol and caffeine restriction are also frequently recommended, but are similarly lacking in supportive research
3 Results 3.1 Effect of DXN and TIR on mortality in rats The therapy schedule and experimental design are illustrated in Figure 1
10.3892/br.2016.630 42
This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated
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