how to switch from semaglutide to tirzepatide Switching dose conversion Switching between weight-loss medications -

the peptide Ac-Nle-cyc/o(- Asp-His-D-Phe-Arg-Trp-Lys)-OH is used in the manufacture of a medicament for intranasal administration for use in the treatment of erectile dysfunction in a male, wherein the peptide Ac-Nle- cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH increases cGMP levels to an amount sufficient to produce an erection sufficient for sexual intercourse when the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp- Lys)-OH is administered at a sub-therapeutic dose and administered subsequent to a sub- therapeutic dose of a PDE-5 inhibitor

The dosing schedule starts at 0.25mg weekly for the first month, then titrates up gradually to the maintenance dose

FDA's April 1 update explicitly confirms that neither semaglutide nor tirzepatide currently appears on either list

PMID: 10793268