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They are formed in the body from normal metabolism (such as converting food to energy), but are increased by exposure to environmental toxins, such as cigarette smoke and air pollution
FIGURE 2 3.3 Anti-cell proliferation and pro-apoptosis effects 3.3.1 p53-dependent cell cycle control and apoptosis p53 is a crucial gene that regulates the balance between cell proliferation and apoptosis through a variety of routes by activating its target genes p21 Waf1/Cip1 and BCL2-associated X protein (Bax)-1
Alexopoulos LG, Youn I, Bonaldo P, Guilak F
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