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One of only two FGF21 analogs tested in a study of biopsy-confirmed NASH patients, pegbelfermin administered daily or weekly for 16 weeks reduced triglycerides by 5% and LDL-cholesterol by about 10% from baseline, while increasing HDL-cholesterol by about 12% and adiponectin by 15% (245)

Generally, six to eight weeks old inbred male and female Swiss albino mice (1:1) weighing 25 to 30 g were requisitioned from the colony maintained under the controlled conditions of temperature (23 2C), humidity (50 5%) and 12 h of light and dark cycle, respectively

Questions remain about substance characterization, dosing, long-term safety information, human research, and the difference between anecdotal use and evidence gathered through larger studies