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Furthermore, periodontal-pathogenic bacteria, if aspirated into the lungs, induce the overexpression of ACE-2 in the alveoli (Sukumar and Tadepalli, 2021), which favors lung inflammation and exacerbated production of proinflammatory cytokines, generating a cytokine storm that induces the destruction of the resident tissue (Yin et al., 2021), caused by T2DM, which favors the severity of COVID-19 disease (Turk Wensveen et al., 2021)
That description is broadly correct but incomplete
Additionally, MAPK has the capacity to modulate SREBP-1 activation and influence mitochondrial fatty acid oxidation, potentially advancing the progression of alcoholic fatty liver disease (AFLD) (Bi et al., 2015)
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