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Plasma levels of active GLP-1 were significantly increased by linagliptin in VilCre control and Gcg RA VilCre mice and, as expected, GLP-1 was not detectable in the plasma of Gcg RA Null mice regardless of treatment (Fig
Both delivery methods produce similar gastrointestinal side effects (nausea, diarrhea, constipation) because these result from the mechanism of action, not the delivery route
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