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Many antioxidant nutrients (folic acid, and vitamin B) and other dietary substances (green tea, and alcohol) are known to affect DNA methylation 43,44

Step 2: Multiply by the dosage

Importantly, increasing the endogenous production of GLP-1 by different mechanisms or by increasing the number of intestinal L-cells that tend to produce this hormone may be another effective therapeutic approach to managing T2DM

This anomaly may arise from confounding factors such as metformin exposure or consumption of polyphenol-rich green tea, though mechanistic validation is pending ( Butyrivibrio , Bifidobacterium bifidum , Megasphaera , Prevotella , Escherichia coli ), which may obscure true microbiota-disease relationships ( 3 Impacts of gut microbiota dysbiosis on gastrointestinal nerves and function In the diabetic state, gut microbiota dysbiosis further exacerbates GI motility dysfunction and impairs the ENS