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The study involved a single-dose, randomized, double-blind, crossover design with tesofensine, placebo, D-amphetamine (used as a positive control for dopaminergic/stimulant effects), bupropion, and atomoxetine (used as negative/unscheduled controls)
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This can range from 600-1200 mg administered 1-3 times per week
and quinones and semiquinones, which are intermediates of melanin biosynthesis, are mutagenic with the capacity to cause cytogenetic instability
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