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Organ and tissue growth concerns Because IGF-1 signaling affects cellular growth and proliferation throughout the body and not exclusively in skeletal muscle, there is concern that long-term use of IGF-1 could result in increased growth of other tissues/organs in the body

Additionally, the hypothesis that elongation of telomeres equates to slowing of the aging process is notoriously hyped and furthermore depends on the supposition that circulating lymphocyte telomere length can be used as a marker for telomere length in body cells overall

Flow cytometry analysis reveals upregulated integrin expression on cell surfaces following TB-500 treatment in various cell line models