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Cost is a common barrier, as most insurance companies do not cover these medications
For peptide options focused on muscle performance, see peptides for bodybuilding
Possible reasons include the longer treatment duration in TRIUMPH-4 (68 vs 40 weeks), differences in how symptoms were captured, and differences in patient populations
Age and baseline wrinkle severity significantly influence comparative effectiveness - younger users (30s-early 40s) with mild expression lines may achieve satisfactory results from peptides alone avoiding Botox entirely, while users in 40s-50s with moderate wrinkles often find peptide-only protocols producing insufficient improvement leading to Botox consideration
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