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The microinfusion delivery quantities are well below systemic concern
Traditionally, GLI proteins are viewed as downstream effectors of the Hedgehog (HH) signaling pathways, but are now also known to be regulated transcriptionally and post-transcriptionally through non-canonical mechanisms involving RAS-RAF-MEK-ERK and PI3K-AKT-mTOR (Dusek and Hadden, 2021)
Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats
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