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In its SMAD pathway, TGF- binds to type II receptors, leading to the phosphorylation of downstream R-SMADs (R-SMAD2 and R-SMAD3) (Jones et al., 2009)
The dissected brains were incubated in 100 nM TMRE solution (Thermo Fisher Scientific) in DSM for 10 min and relative fluorescence intensity was quantified by top excite-read method through Synergy H1 reader
Furthermore, temporary discontinuation of the drug led to the recurrence of psoriatic lesions, with subsequent improvement in the PASI score upon reintroduction [13]
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