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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

A detection window describes how long a specific assay, at a specific limit of quantification, in a specific matrix urine, serum, dried blood spot can still identify a compound or its metabolites

In that sense, B12 injections can support the conditions that make weight loss easier to maintain

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