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Nothing supports reaching for an awkward or unsafe site to satisfy the principle
A study by our group [80] showed that when erythrocytes were saturated with CO, the enzyme Prx2 was present in the cytosol only in the monomeric form, suggesting that Prx2 was not acting as a peroxidase but, instead, exclusively as a chaperone for Hbs protection
doi: 10.1007/82_2018_137
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