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A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance
These mechanisms are thought to mitigate T-cell loss and senescence, thereby supporting more robust immune reconstitution once viral suppression is achieved
[4] [7] It is administered as a once-weekly subcutaneous injection, with doses gradually titrated from 0.25 mg to a maintenance dose of 2.4 mg over 1620 weeks
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