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The most frequently reported adverse effects relate to the gastrointestinal system rather than direct cardiac effects, including nausea (occurring in approximately 15-20% of patients according to the SmPC), vomiting, diarrhoea, and constipation
Documentation of alcohol consumption, over-the-counter medication use, and herbal supplements at each review helps identify potential hepatotoxic exposures that may confound interpretation of liver function changes
Going into the protocol with that understanding tends to produce better adherence and better long-term outcomes than approaching it as another test of discipline
The decision about which baseline tests (if any) should be based on your individual health history and goals, not a standardized protocol applied to everyone
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