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A 2025 meta-analysis of 12 RCTs involving more than 25,000 participants showed no elevated risk of any cancer type, including thyroid (RR 1.07, 0.225.12 p = 0.93), pancreatic (RR 0.85, 0.107.43 p = 0.89), or gastrointestinal malignancy (RR 0.73, 0.262.04 p = 0.54) [147]

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Leptin is also secreted by the placenta, which is why leptin levels (and thus hunger) increase during pregnancy.[ref] Leptin resistance and depression: In men and women with type 2 diabetes, high leptin levels correlate with depression and anxiety