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Patients with a personal or family history of polycythemia, cardiovascular disease, sleep apnea, or liver dysfunction face elevated risks with testosterone

Drawing through the rubber stopper of a vial dulls the tip, and a dull needle hurts more going through skin

The most commonly reported side effects for both agents are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

This oxidative damage is evidenced by elevated levels of 8-hydroxydeoxyguanosine, indicating compromised DNA integrity that facilitates mutations in melanoma-related genes like BRAF and loss of tumor-suppressor functions 119