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Almost always with a start-low, go-slow approach: the lowest available dose first, then gradual increases over several weeks
Other risk factors include skipping meals, intense exercise without carbohydrate intake, alcohol consumption (especially without food), and rapid dose escalation of semaglutide
Tirzepatide has a roughly 5-day half-life, so there will still be residual drug in your system when you begin sublingual dosing
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