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This result may have been driven by Erysipelatoclostridium and Lactobacillus , the only two microbial genera that significantly differed between the 5A-1MQ-treated and the vehicle-treated mice both switched from WD to LD

Patients with established hypertension should have blood pressure measured at baseline and at each dose escalation (typically every 4 weeks during titration), then every 36 months once stabilised

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