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Animal acute toxicity studies across Sikiric's group publications have consistently shown a low acute toxicity profile, with no defined lethal dose identified in standard rodent models
However, the GLP-1 receptor/GIP receptor/GCGR triple agonist retatrutide showed strong glucose-lowering and weight-lowering efficacy (HbA 1c reduction of 22.4 mmol/mol [2.01%] at 24 weeks and body weight reduction of 13.9% at 36 weeks, placebo subtracted) during a Phase 2 trial in overweight/obese individuals with type 2 diabetes [61]
c 1998-2022
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