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However, conflicting evidence highlights context-dependent risks, such as early DR worsening in poorly controlled glycemic states

These vitamins play an essential role in the metabolic processes of both the central nervous system (CNS) and the peripheral nervous system (PNS)

11 Serious AEs were reported infrequently in PIONEER 1 to 5, and 8 to 10, occurring in 0% to 14% of patients across all treatment groups at a similar frequency between treatment groups in each of the trials

But those drugs are no longer in shortage, and the FDA has warned the public about taking compounded drugs when it isnt medically necessary