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Its the first medication targeting the amylin pathway to reach phase 3 trials, and that pathway is generating real industry momentum
Neurological changes A lack of vitamin B12 can cause neurological problems, which affect your nervous system, such as: vision problems memory loss pins and needles loss of physical co-ordination (ataxia), which can affect your whole body and cause difficulty speaking or walking damage to parts of the nervous system (peripheral neuropathy), particularly in the legs If neurological problems do develop, they can sometimes be irreversible
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There's a clinical nuance worth noting, though
Niihara H, Kaneko S, Ito T, Sugamori T, Takahashi N, Kohno K, Morita E (2013) HLA-B*58:01 strongly associates with allopurinol-induced adverse drug reactions in a Japanese sample population
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