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Materials and methods This study was designed following the framework delineated by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [17] with rigorous attention given to registering the study protocol in the International Prospective Register for Systematic Reviews (PROSPERO) (registration code: CRD42023466256)
Pancreatic Inflammation & Potential Pancreatic Damage While GLP-1 receptor agonists (e.g., Ozempic, Wegovy, Mounjaro) are widely used and carry established warnings for acute pancreatitis, extensive large-scale studies show the overall absolute risk remains very low, and long-term data indicates they do not increase the lifetime risk of pancreatic damage for most patients Pancreatitis is a known risk of GLP-1 drugs, but long-term consequences are still being studied
Nivaan Health selected tirzepatide for its dual GIP/GLP-1 receptor mechanism, which clinical data associates with fewer gastrointestinal side effects and greater weight reduction compared to single-receptor GLP-1 agonists
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