contraindication to glp 1 contraindications for glp-1 agonists include Ten Top Tips the Management of Receptor in Adults within Primary Care Emergency Presentations of GLP-1 Agonist – GLP-1 Safety: Who Shouldn't Use

If GLP-1s arent an option for you, work with a healthcare provider trained in obesity medicine

Of those 161 patients, 16 (10%) experienced recurrent acute pancreatitis after GLP-1 receptor agonist therapy (mean duration 10.8 7.2 months): 6 (38%) were caused by the GLP-1 receptor agonist (as clinically determined by the treating medical team), three (18%) were due to hypertriglyceridemia, two (12%) due to alcohol use, one (6%) due to another oral hypoglycemic agent, one (6%) due to ampulla stenosis, and three (19%) were idiopathic

SIRT5 activity is the major mitochondrial de-succinylase but also functions within the nucleus

K.et al (2009)