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The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment
The optimal target is 160 grams
Alternatively, GLP-1 may act directly on the renin-secreting cells of the juxtaglomerular apparatus, where the expression of GLP-1 receptors has been detected (69)
Solution : Implement cost containment strategies like step therapy, prior authorization, and exploring alternative medications to help manage the financial impact of GLP-1s
US$ 21.98
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