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[2] The Boc/Bzl strategy utilizes TFA-labile N-terminal Boc protection alongside side chain protection that is removed using anhydrous hydrogen fluoride during the final cleavage step (with simultaneous cleavage of the peptide from the solid support)
This FDA review signals a shift
It also shifts melanin production from the darker eumelanin toward the lighter pheomelanin, which is why it is used for skin brightening
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