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Structural abnormalities, bone-related problems, and advanced degenerative changes show limited response regardless of treatment duration
Among hypoglycemic drugs, sulfonylureas secretagogues and glinide secretagogues can increase the risk of skeletal muscle atrophy, metformin may have adverse effects on skeletal muscle mitochondrial function, and sodium-glucose transporter 2 inhibitors (SGLT2i) increase the risk of sarcopenia [13]
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