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1.1 Role of complementary and integrative medicine in breast cancer Conventional therapies have improved our understanding of the disease and increased survival rates, but they may not be able to address the complete range of physiological, psychological, or quality-of-life needs that breast cancer patients may have, which is why complementary or integrative medicine (CIM) has emerged as a vital component of overall breast cancer treatment ( Widely studied supplements include curcumin, green tea catechins (EGCG), resveratrol, quercetin, genistein (soy isoflavones), omega-3 fatty acids, silymarin, ashwagandha and vitamins D and selenium as well as some of the mushrooms such as Ganoderma lucidum many of which have preclinical evidence for inhibiting tumour proliferation, chemosensitizing cancer cells modulating oestrogen receptor signalling decreasing oxidative stress or stimulating immune surveillance ( Unlike prior reviews that primarily summarize bioactive compounds, the present manuscript adopts an integrative translational framework that combines molecular mechanisms, clinical evidence, safety evaluation, pharmacokinetic considerations, nano-delivery innovations, and precision oncology perspectives

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