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If you are self-supplementing with high-dose B12 without medical indication, discuss this with your GP

Diet and Nutritional Advice: Patients should also be advised to maintain a balanced diet to prevent future deficiencies, emphasizing foods high in thiamine such as whole grains, nuts, and legumes, alongside B-complex vitamins if necessary, to support overall health

The Stanford University Institutional Review Board deemed this study exempt from ethical review and the requirement for informed consent because no human participants were involved