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Clinically, in patients with renal failure, acute kidney injury, dialysis and other pathological states of renal function deterioration, renal reabsorption function is impaired, resulting in a significantly lower serum free carnitine concentration than that in healthy people [255], and the metabolic profile of acylcarnitine also changes significantly [256]
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It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention
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