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In the HIACE RCT, Tse et al
CrossRef The effects of shRNA-mediated gene silencing of transcription factor SNAI1 on the biological phenotypes of breast cancer cell line MCF-7 Yan Lu, Lina Yu, Minlan Yang, Xiangshu Jin, Zhijing Liu, Xiaowei Zhang, Liping Wang, Dongjing Lin, Yuanyuan Liu, Min Wang, Chengshi Quan Molecular and Cellular Biochemistry.2014
Additionally, some incidents go unreported due to other underlying health conditions
The second promising concept is creating redox-directed anticancer prodrugs that convert to active parent drugs in vivo by antioxidant enzymes that are specifically overexpressed in cancer
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