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Given that trypsin possesses distinct biochemical properties, structural features, and physiological context compared to TMPRSS2, it may not fully replicate the spatiotemporal regulation required for TMPRSS2-dependent spike proteolytic activation

Consequently, findings from SH-SY5Y cells may not fully translate to in vivo conditions or capture the complex pathophysiology of the human brain

If the switch is due to your insurance formulary, your prescriber may also need to handle prior authorization paperwork or update your records to reflect the change