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The co-expression of ST and RAS V12 leads to the upregulation of topoisomerase I, thereby increasing cellular susceptibility to Erastin (Yagoda et al., 2007

They claimed that augmented ferroptosis enhanced the antitumor actions of CD8 + T lymphocytes by stimulating ferroptosis and lipid peroxidation in tumor cells using tumor immunotherapy with a programmed death-ligand 1 (PD-L1) antibody

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Representative domains include: Gastrointestinal and hepatic models: Protection against ulcers, leaky gut, IBSlike symptoms, Crohntype inflammation, and toxic liver injury (e.g., CCl4, NSAID, and alcohol models), with improved mucosal healing and barrier integrity