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Prolonged compensatory mechanisms in response to regional dysfunction exacerbate the mechanical load on the heart, ultimately inducing myocardial hypertrophy

Paracetamol (maximum 4 g daily) is a safe first-line option for most patients, whilst ibuprofen (maximum 1.2 g daily for over-the-counter use) may be used if paracetamol proves insufficient, provided you have no contraindications such as kidney disease or gastric ulcer history

Some studies report stable or slightly improved bone density with GLP-1 therapy, while others suggest potential decreases, particularly in the context of significant weight loss

These studies, ranging from 1.5 to 4 years, show that semaglutide remains safe and effective to take long-term