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You don't do the same thing with blood pressure, "Well, I'll come off my blood pressure meds or cholesterol meds, and see how I do. Some patients may be good candidates for medical therapy alone, particularly those with borderline BMI who have access to medication and do not have conditions such as reflux or a history of pancreatitis, which can be worsened by GLP-1s

Obesity Research: Pre-clinical obesity studies have reported substantial effects on body weight, food intake, and fat mass in animal models, with research attributing the breadth and magnitude of these effects to the combined tri-receptor mechanism particularly the additive contribution of glucagon receptor-driven energy expenditure alongside dual incretin activity