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Inflammation and fibrosis are distinct disease processes, and a drug may improve one without affecting the other

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These check-ups can help identify risk factors and catch any early signs of optic nerve issues before they progress to NAION

Occupancy stays low, but each engaged receptor keeps sending its main message longer than it would under a balanced signal (cAMP bias with low receptor internalization). In a head-to-head trial against liraglutide, tirzepatide reduced measured food intake and craving more despite lower GLP-1 occupancy. The effect lowers the drive to eat rather than increasing restraint