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Common Side Effects Nausea Diarrhea Vomiting Constipation Stomach Pain Decreased Appetite Headache Serious Side Effects (less common) Possible inflammation of the pancreas (pancreatitis) Gallbladder issues Kidney problemsoften linked to dehydration caused by symptoms like nausea or vomiting Serious allergic reactions Vision alterations, particularly in patients with type 2 diabetes Increased heart rate Notably, oral semaglutide includes a boxed warning related to risks of thyroid C-cell tumors, although these findings were primarily based on animal studies