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Alpha-adrenergic agonists: Limited (and often very small) studies of Clonidine and Guanfacine report improvements in behaviors such as hyperactivity, impulsivity, stereotypies, self-stimulation, inappropriate speech, irritability, aggression, and oppositional behavior as a frequent side effect in individuals with ASD
Some researchers find that injecting in the evening before sleep allows them to sleep through the worst of any initial nausea
Topical reactions: rare irritation , redness or dryness , especially at 3 %+ percentages on sensitive skin
Its also more soothing, which can reduce signs of redness
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