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Serious but rare adverse effects include pancreatitis, gallbladder disease, acute kidney injury (usually secondary to dehydration from gastrointestinal symptoms), and hypoglycemia when combined with insulin or sulfonylureas

et al., 2023), the administration of GPS was observed to markedly elevate adiponectin concentrations while reducing resistin levels

Potential Negative Effects on Mental Health While the potential benefits are encouraging, its crucial to acknowledge the potential negative impacts of GLP-1 inhibitors on mental health: Increased Anxiety and Agitation: Paradoxically, while some studies suggest anxiety reduction, others have reported instances of increased anxiety, restlessness, and agitation in individuals taking GLP-1 agonists