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It must be injected subcutaneously or intramuscularly for bioavailability
For visceral fat specifically, peptides targeting visceral fat loss include compounds that may require shorter treatment durations than GLP-1 agonists
Only a subset of participants aged 55 and older showed a modest benefit approximately a 1 percentage point reduction in HbA1c (from 8.6% to 7.7%) and a slight increase in fasting insulin
Initial small trials from 2016 to 2017, including EXSCEL, FIGHT, and LIVE, were not supportive of the use of GLP-1RAs in HFrEF with negative outcomes related to cardiovascular events [53,54,55]
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