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This is partially because men typically carry more visceral fat, which responds quickly to the metabolic changes GLP-1 creates

Other GLP-1RAs (liraglutide) also elevated phosphorylation of ERK with increased transcriptional activity and the inhibitors of PD98059 and GLP-1R siRNA partially blocked the liraglutide-induced ERK signaling activation (Wu et al., 2017)