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If NAPQI depletes GSH stores and the production of NAPQI exceeds that of GSH, the hepatotoxic substance accumulates and kills liver cells (15)
Several ACOT genes are also identified with the THEM nomenclature with ACOT11 being identified as THEM1 and ACOT13 being identified as THEM2
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This means that while its origin is rooted in a natural biological component, the compound itself is a manufactured entity, which has significant implications for its classification and oversight by regulatory bodies
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