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However, since ML348 inhibits other substrates of APT1 as well, its action is not ER-specific, suggesting that the development of specific drugs targeting palmitoylation of ER still requires further studies (179)

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Alternative repletion strategies have focused on oral administration of GSH precursors (e.g., cysteine and glycine supplementation 9 ), and intravenous administration of GSH, 10 which although promising, is invasive and inconvenient, and therefore unlikely to be a practical solution

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