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According to a randomized, double-blind, placebo-controlled, matched-pair study by Watanabe et al

Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition

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More importantly, BAY 11-7082 treatment also rescued the aggravated SGN loss and apoptosis induced by the deficiency of GPX1 after peroxynitrite injury, as the number of SGNs was added, whereas the C-CASP3 expression was reduced in the peroxynitrite + gpx1 / + BAY 11-7082 group vs