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Because both vitamins affect red cell size, a raised MCV can also be a clue when the B12 looks comfortable

Grading quality of evidence and strength of recommendations

Some studies have shown that metformin can reduce the absorption of vitamin B12 in 30% of people with type 2 diabetes (Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy)

Vitamin B12, also known as cobalamin, is an important water-soluble vitamin involved in red blood cell production, brain health, and DNA synthesis ( A deficiency in this key vitamin can cause serious symptoms, including fatigue, nerve damage, digestive issues, and neurological problems like depression and memory loss ( Therefore, many people turn to vitamin B12 supplements to help meet their needs and prevent a deficiency