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Important measures include: Percentage of starting weight lost Waist circumference Hunger and craving control Medication tolerance Protein and calorie intake Strength and physical activity Blood pressure Glucose or hemoglobin A1C when indicated Changes in relevant medications A reduction of at least 5% of starting body weight is considered clinically meaningful and may improve several obesity-related health risks

Mounjaro is also a particularly good fit for people who have type 2 diabetes alongside obesity

The dual GIP/GLP-1 action of tirzepatide may influence this process, as GIP receptors are expressed in adipose tissue and may play a role in lipid metabolism

While it does lead to weight loss, it is significantly less effective than both semaglutide and tirzepatide and requires daily injection