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Many genes associated with IR are downregulated in the AT of PWS subjects [25]
In Phase 2/3 trials, participants lost an average of 24-29% of body weight at the highest doses over 48-68 weeks
In studies involving nonhuman primates, GSBR-1290 showed a dose-dependent increase in insulin secretion, improved glucose control, and a decrease in both food intake and body weight
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